The concept of tonics has been cornerstone of various systems of traditional medicine, serving as agents that restore vitality, enhance resilience, and promote overall well-being. In modern biomedicine, related concepts are explored under terms such as adaptogens, immunomodulators, and organ-supportive therapies, yet these approaches often remain fragmented and lack the integrative orientation found in traditional systems. Within Unani medicine, Muqawwiyāt are deeply embedded in the philosophical foundation that views health as a dynamic balance between temperament, faculties, and structure of body. Unlike modern pharmacotherapy, which targets isolated pathophysiological processes, Muqawwiyāt operate within a holistic paradigm that unites prevention, restoration, and rejuvenation. This review explores the theoretical and functional dimensions of Muqawwiyāt. It further draws parallels with analogous concepts of tonics across other traditional healing systems, including Ayurveda and Traditional Chinese Medicine, to provide a comparative understanding. By examining both classical interpretations and potential mechanistic insights such as modulation of metabolism, enhancement of cellular energy, and regulation of stress responses this review aims to bridge traditional Unani wisdom with contemporary scientific perspectives. Ultimately, it underscores the enduring significance of Muqawwiyāt as a comprehensive therapeutic paradigm that unites traditional principles of health preservation with contemporary concepts of physiological resilience and adaptive capacity.