Life Science Research Communications

Encephalopathy Associated with H3N2 Influenza: Alarming Art of State

Abhishek Kumar, Kiran Dobhal, Parul Bisht, Sayantan Mukhopadhyay

H3N2 influenza viruses are among the prevalent strains causing seasonal flu in humans. While respiratory symptoms have been the hallmark of influenza infections, neurological complications such as encephalopathy associated with H3N2 viruses have garnered attention due to their severity and implications for affected individuals. The pathogenesis of H3N2-induced encephalopathy involves multifaceted mechanisms, including direct viral invasion, immune-mediated responses, and neuro-inflammatory processes. Children and the elderly are particularly vulnerable, and the manifestation of symptoms varies from mild cognitive impairment to severe encephalitic conditions. Diagnosis remains challenging due to overlapping symptoms with other encephalopathies and the rapid onset of neurological deficits during the acute phase of influenza infection. The present review provides an overview of the current understanding of H3N2 virus-associated encephalopathy in humans and case studies associated with it.