Diabetic Foot Ulcers (DFU) are the leading cause of non-traumatic lower extremity amputations, placing a huge burden on the entire healthcare system and significantly reducing patient’s quality of life (Yarahmadi et al., 2021). Despite many efforts to address this issue and treat patients suffering from DFU, there is no satisfactory treatment that can prevent long-term complications of DFU (Hu et al., 2025). Wound healing is a process involving many intricate signaling pathways that occur upon tissue damage (Yarahmadi et al., 2021). Wound healing is divided in four well-organized phases named homeostasis, inflammation, proliferation and remodeling (Yarahmadi et al., 2021). In DFU, into these four phases of wound healing are disrupted mainly due to inflammation and oxidative stress resulting from the long-term hyperglycemia of diabetes (Yarahmadi et al., 2021).