Introduction: the current epidemic of COVID-19 requires a lot of efforts to be controlled involving pharmacotherapy and clinical pharmacology studies. Aim: to introduce a brief review of drugs under investigation for COVID-19. Materials and Methods: Our project is a systematic review of many medications being studied for their effectiveness and safety in COVID-19 management. Results: Antiviral drugs (osletmivir, ramdisvir), corticosteroids (dexamethasone), immunomodulators (anakinera, toculizumab), antithrombotic (antiplatletes, anticoagulants) are still under investigation although preliminary results are promising. Conclusion: Yet, few medications have been approved by FDA for management of COVID-19 but drugs have been used in clinical trials under FDA emergency use authorization. Ongoing clinical trials are essential to establish their long-term safety and effectiveness. Key points: 1. Scientists are testing different medicines, such as antivirals, steroids, immune-boosting drugs, and blood thinners, to see if they can help treat COVID-19. 2. Some of these drugs show early promise, but only a few have official approval for use. 3. More research and clinical trials are needed to make sure these treatments are safe and work well in the long run.